Reddy vaagdevi college of pharmacy, ramnagar, hanamkonda, warangal 506001, ap, india. This article needs attention from an expert in medicine. Hepatoprotective effects of moringa oleifera leaf extract. Plant extracts can be the best source of such antioxidants and mediate hepatoprotective activity. Hepatoprotective activities of triphala and its constituents. Ram manohar lohia avadh university, faizabad224001, uttar pradesh, india. N college of applied sciences, simoga, karnataka, volume 38 year 2006 page 2528. Liver weight and volume, biochemical estimations, such as measurement of transaminase activity, sgpt, scot, alkaline phosphatase, serum bilirubin, total serum proteins, albumin, globulin and prothrombin time, functional parameters, pentobarbitone.
Hepatoprotective activity of the methanolic extract of the. In addition, the reducing power of the extracts and their ability to scavenge free radicals were evaluated using two antioxidant assay systems. International journal of science and research ijsr is published as a monthly journal with 12 issues per year. Vp pharmacy college, georai tanda, aurangabad, maharashtra, pravara rural college of pharmacy, loni, ahemednagar. Hepatoprotective activity of flavonoids is due to their ability to scavenge free radicals.
Thirupathy kumaresan1, arunjosph, gururajesh u, renugadevi,c sathish kasula department of pharmacology, arulmigukalasalingam college of pharmacy, krishnankoil 626126, virdhunagar dist,tamilnadu,india. The purpose of this research was to assess the hepatoprotective effect of crude aqueous leaf extract of f. Patel sapan 2009, have also did the same type of work of baitul district of m. Hepatoprotective activity of the methanolic extract of the bark of khaya senegalensis in rats against paracetamol induced hepatotoxicity. Iv hepatoprotective activity of date palm phoenix dactylifera pollen grains in rats by itimad abuowf ahmed abuowf b. Structurehepatoprotective activity relationship study of. Hepatoprotective and antioxidant activities of hepacare, a herbal formulation against carbon tetrachlorideinduced liver injury tetrachloride ccl 4 is a hepatotoxin widely used in animal models, biotransformed by hepatic microsomal cytochrome p 450 to produce the trichloromethyl free radicals 5 which can react. 5187651881 june 2017 with 2,852 reads how we measure reads. Hepatoprotective activity of ocimum sanctum alcoholic leaf. Models of hepatoprotective activity assessment sciencedirect. In their pdf hepatoprotective on thesis activity revisions, students may have been a major consideration for everyone, so experiment to find a permanent part of college life. The most commonly used parameters to assess the hepatoprotective activity are morphological e. The hepatoprotective activity was studied by observing the effect of these herbal extracts on tbh induced reduction in cell viability of hepg2 cells. Assessment of hepatoprotective activity methanolic and water extracts of fagonia cretica l.
The hepatoprotective activity of the plant may be attributed to the phenolic compounds, flavonoids, and saponins 6164. The effects observed were compared with a known hepatoprotective agent, silymarin. Hepatoprotective activity of cardiospermum helicacabum stem extracts against carbontetrachlorideinduced hepatotoxicity in wistar rats arjumand ara, srinivas reddy. Wistar albino rats weighing 90100 g of either sex maintained under standard husbandry conditions temp 23 2c, relative humidity 55 10% and 12 hours light dark cycle were used for the screening. An institutional investigation by the university of malaya found there was no system to index and. Hepatoprotective activity of tectona grandis against ccl4. Hepatoprotective and antioxidant activity of standardized. Introduction in ancient indian literature, it is mentioned that every plant on this earth is useful for human beings, animals and other plants. For instance, students at this style of writing or resented among esl learners. Hepatoprotective activity of date palm phoenix dactylifera pollen grains in rats by itimad abuowf ahmed abuowf b. Coldenia procumbens linn, isoniazid, pyrazinamide, rifampicin, mtt assay. Hepatoprotective and antioxidant effect of stem barks. Mohammed ishaq 3 deccan school of pharmacy 1, hyderabad, andhra pradesh, india. Hepatoprotective activity of against cclinduced hepatic.
National institute of allergy and infectious disease, national institute of health. International journal of scientific and research publications, volume 4, issue 3, march 2014 3 issn 22503153. Hepatoprotective and antioxidant activities of hepacare, a. Hepatoprotective activity modified method of chandra et al32, was adopted in this study. Evaluation of hepatoprotective and antioxidant activity of ichnocarpus frutescens linn. In vitro and in vivo hepatoprotective activity of cissampelos.
Agrawal, hepatoprotective activity of emebelia ribes against paracetamol induced acute hepatocellular damage in mice, experimental medicine, 2003, vol. Evaluation of hepatoprotective activity of tectona grandis seeds by using ccl4 induced hepatic injury in rats. The present study was designed to assess the hepatoprotective activity and cytotoxicity of methanolic and water extracts of f. University of khartoum 1993 a thesis submitted in partial fulfillment of the requirements of the university of khartoum for the degree of master in tropical animal health mtah. Hepatoprotective activity of panchegavya ghrita against carbontetrachloride induced hepatotoxicity in rats. Oral administration of an aqueous extract of andrographis 10, 20 and 30 mg per mouse caused a significant elevation of catalase, sod and glutathionestransferase activities in lymphoma. Evaluation of hepatoprotective activity of ethanolic. Kalol institute of pharmacy, kalol, gujarat accepted date. Evaluation of the hepatoprotective activity of fagonia. The hepatoprotective activity of conyza bonariensis ethanol extract was studied against paracetamol induced hepatotoxicity in mice. Hepatoprotective and antioxidant activity of standardized herbal extracts article pdf available in pharmacognosy magazine 830. Pharm, pharmacology department of pharmacology declaration of the candidate i hereby declare that the thesis titled evaluation of hepatoprotective activity of ethanolic extract of polygonum glabrum willd on hepatotoxicity induced rats submitted in partial fulfillment for the award of degree master of.
These extracts were studied for their hepatoprotective activity using. The small amount of substance mixed with equal volume of fehlings a and fehlings b solution and heated in a. K, hepatoprotective activity of pterocarpus santalinus, department of botony, s. Three studies cited above attest to significant in vivo and in vitro antioxidant activity for the herb, 87,93,100 as do some of the hepatoprotection studies. Medical university, chennai, in partial fulfillment for the award of degree of master of pharmacy in pharmacology is a bonafide individual research work done by h. It is a nontoxic hepatoprotective substance from the himalaya drug co. Oxidative stress and free radicals enhance the severity of hepatic damage, which can be overcome by the antioxidant mechanism. The liver performs a vital role in metabolism, secretion, storage, and detoxification of endogenous and exogenous substances. D763600004 vinayaka missions university salem tamilnadu, india,he. Ficus benjamina with a stock dose of 500 mgml given via oral. In vitro antioxidant activity and hepatoprotective potential.
Hepatoprotective activity of cardiospermum helicacabum stem. Dcfhtoxicated cells were recovered to about 100% with 100. Antioxidant and hepatoprotective activity of aqueous extract of solanum fastigiatum false jurubeba. In vitro antioxidant activity and hepatoprotective. Hepatoprotective activity of basella rubra linn against ethanol induced hepatotoxicity in male wistar albino rats dissertation submitted to the tamil nadu dr. The scientific world journal has retracted the article titled passpredicted hepatoprotective activity of caesalpinia sappan in thioacetamideinduced liver fibrosis in rats. Hepatoprotective activity of ethanolic extract of polygonum glabrum willd on hepatotoxicity induced rats submitted to the tamilnadu dr. These were divided into 4 groups of 6 animals each. The present paper deals with the survey of such plant based on folklore information used in. Paukku y, rasulev b, syrov v, khushbaktova z, leszczynski j. Hepatoprotective activities of triphala and its constituents rasna gupta1, ankit gupta2, ram lakhan singh1 1.
This is the first report of the hepatoprotective activity of the plant. The ceropegia spiralis was evaluated for in vitro antioxidant activity by 2, 2diphenyl1picryl hydrazyl dpph, hydroxyl and. The magnitude of the hepatoprotective effect can be measured through biochemical makers, survival rate or histology of the liver. Zygophyllaceae herb is widely distributed in sudan and used in sudanese traditional medicine for the treatment of various disorders. Hepatoprotective activity of ethanol extract of conyza b. Hepatoprotective activity of some medicinal plants in sudan. Sat kaival college of pharmacy, sarsa, gujarat, india 3. Hepatoprotective activity of various plants hepatoprotective activity of pterocarpus santalinus.
B 250 mgkg and 500 mgkg produced p hepatoprotective and antioxidant activity of ichnocarpus frutescens linn. Thesis on hepatoprotective activity pdf with language arts. Most iaas vendors are cloud computing where computing resources as in toy and oil, the proper foundations for a new myth, says the. Hepatoprotective activity of cardiospermum helicacabum. Becomes loses the tooth for money, covered in gold.
Nutraceutical laboratory, department of biochemistry, dr. Hepatoprotective activity studies of herbal formulations. Hepatoprotective effects of moringa oleifera leaf extract on. Study of the ethanomedicinal plants of bhopal district of. University of khartoum 1993 a thesis submitted in partial fulfillment of the requirements of the university of khartoum for the degree of master in. Green tulsi ocimum sanctum, belonging to family lamiaceae are used traditionally for their hepatoprotective effect. Hepg2 cells showed significant dose dependent increase in percentage viability at the doses 20, 40, 60, 80 and 100 gml of cpre compared to ccl 4 exposed hepg2 cells.
Hepatoprotective effect of crude aqueous leaf extract of fig tree, ficus benjamina, on ethanolinduced liver damage in mice. Invitro hepatoprotective activity of moringa oleifera mediated synthesis of gold nanoparticles t. Melia azedarach, hepatoprotective activity, simvastatin, ethanol and silymarin. Hepatoprotection or antihepatotoxicity is the ability of a chemical substance to prevent damage to the liver. Hepatoprotective activity of cardiospermum helicacabum stem extracts against 489 in acute toxicity studies, none of the extracts studied showed any toxic symptoms or caused death of mice even after 48 hrs at all the doses of the extracts studied. Structurehepatoprotective activity relationship study of sesquiterpene lactones.
Figures c and f were reused from figures c and d in an article by the same authors, kadir et al. Invitro hepatoprotective activity of moringa oleifera. Wong, phd thesis on hepatoprotective activity wingtak. Ragunathan department of biomedical engineering, sathyabama university, rajiv gandhi salai, chennai, india centre for bioscience research centre, eachanari, coimbatore, india. Wikiproject medicine may be able to help recruit an expert. We wanted to evaluate the hepatoprotective activity of ocimum sanctum and observe whether synergistic. The annual volume of phyllanthus trade in india is estimated to be about 2,0005,000 metric tonnes of herbaceous material and about 16,00018,000 metric tonnes of fruits ved and goraya, 2008. Medical university, chennai in partial fulfillment for the award of the degree of master of pharmacy in pharmacology by meena g register no.
Structure hepatoprotective activity relationship study of sesquiterpene lactones. Sitha institute of pharmaceutical sciences 2, hyderabad. The annual volume of phyllanthus trade in india is estimated to be about 2,0005,000 metric tonnes of herbaceous material and about 16,00018,000. The objective of hepatoprotective models is for the compounds, fractions or extracts being tested to counteract or avoid the damage generated by hepatotoxins. Investigation of medicinal plants for hepatoprotective activity thesis submitted to partial fulfillment for the award of degree of doctor of philosophy in p harmacy submitted by p. Evaluation of hepatoprotective and antioxidant activity of. Evaluation of hepatoprotective activity of ethanolic extract of. Protecting the liver from the harmful effects of hepatotoxins which may be ingested or counteracting the alterations in the antirradical defense mechanisms, is very important. Hence, it was proposed to carry out a preliminary in vitro analysis of the hepato protective activity of the plant, which gave promising results. Atherosclerosis is a condition that develops when plaque, mostly made up of white blood cells and blood fats like cholesterol and triglycerides, builds up in the walls of the arteries. The liver is the key organ regulating homeostasis in the. Hepatoprotective and antioxidant activities of hepacare. The study was designed to evaluate the hepatoprotective activity of p. Significant hepatoprotective activity of ocimum sanctum was reported earlier against paracetamol, carbon tetrachloride and antitubercular druginduced hepatoxicity in albino rats.
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